青光眼ONF损害是由眼压、免疫、血循环等多因素共同作用的结果，相同的因素在不同类型青光眼发病中所发挥的作用大小不同，不同的因素也可以在同一类型青光眼中发挥协同作用[36,37]。既往有关青光眼ONF损伤的研究多建立在回顾性研究的基础上，只有加强对各种可能导致ONF损伤的因素进行有干预的前瞻性研究，才能详细了解每种因素对ONF损伤的机制，从而有针对性地提出相应的治疗方法，改变目前青光眼治疗方式单一的状况。
【参考文献】
1 Quigley HA, Addicks EM, Green WR, Maumenee AE. Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol. 1981;99(4):635-649
2 Quigley HA, Addicks EM, Green WR. Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy. Arch Ophthalmol. 1982;100(1):135-146
3张承芬，主编.眼底病学.第2版,北京:人民卫生出版社,1998：506
4 Hayreh SS．Blood supply of optic nerve head in health and disease．In：Lambrou G,Greve E. Ocular Blood Flow in Glaucoma．Berkeley,CA.Kugler Publications，1989:3-48
5 Wax MB, Tezel G, Kawase K, Kitazawa Y. Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States. Ophthalmology. 2001;108(2):296-302
6 Romano C, Li Z, Arendt A, Hargrave PA, Wax MB．Epitope mapping of anti-rhodopsin antibodies from patients with normal pressure glaucoma. Invest Ophthalmol Vis Sci. 1999; 40(6): 1275-1280
7 Morrison JC, Johnson EC, Cepurna W, Jia L. Understanding mechanisms of pressure-induced optic nerve damage. Prog Retin Eye Res.,2005;24(2):217-240
8葛坚，孙兴怀，王宁利,主编.现代青光眼研究进展. 北京：科学出版社，2000：67-68
9 Foster PJ, Buhrmann R, Quigley HA, Johnson GJ. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol ,2002;86: 238-242
10葛坚，孙兴怀，王宁利,主编.现代青光眼研究进展. 北京：科学出版社，2000:15
11范军华，叶瑞珍，陈小春，黄雪丽.用Heidelberg视网膜断层扫描仪对正常眼压性青光眼与正常人视盘形态结构的对比研究.中国实用眼科学杂志，2004;22(7)：509-511
12葛坚,主编.眼科学.第1版，北京：人民卫生出版社,2002:154
13 Cartwright MJ, Anderson DR. Correlation of asymmetric damage with asymmetric intraocular pressure in normal-tension glaucoma (low-tension glaucoma).Arch Ophthalmol,1988;106：898
14 Haefliger IO, Hitchings RA．Relationship between asymmetry of visual field defects and intraocular pressure difference in an untreated normal (low) tension glaucoma population. Acta Ophthalmol (Copenh) ,1990;68(5):547-567
15 Drance SM,Douglas GR,Wijsman K, Schulzer M, Britton RJ. Response of blood flow to warm and cold in normal and low-tension glaucoma patients. Am J Ophthalmol.1988;105:35-39
16 Samuelson TW, Spaeth GL. Focal and diffuse visual field defects: their relationship to intraocular pressure . Ophthalmic Surg ,1993;24(8):519-525
17 Cartwright MJ, Grajewskt AL, Frtedberg ML, Anderson DR, Rtchards DW. Immune-related disease and normal tension glaucoma. Arch Ophthalmol,1992;1l0:500-502
18 Jonas JB, Grundler AE, Gonzales-Cortes J. Pressure-dependent neuroretinal rim loss in normal-pressure glaucoma. Am J Ophthalmol ,1998;125(2):137-144
19 Kamal D, Hitchings R. Normal tension glaucoma—a practical approach.Br J Ophthalmol ，1998;82:835-840
20 Sossi N，Anderson DR．Effect of elevated intraocular pressure on blood flow. Occurrence in cat optic nerve head studied with iodoantipyrine I-125. Arch Ophthalmol ,1983; 101(1):98-101
21 Abedin S, Simmons RJ, Grant WM. Progressive low-tension glaucoma.Ophthalmology ,1982;89:16
22 Yamamoto T, Ichien M, Suemori-Matsushita H, Kitazawa Y. Trabeculectomy with mitomycin-C for normal tension glaucoma. J Glaucoma,1995;4:158-163
23 Bhandari A, Crabb DP, Poinoosawmy D, Fitzke FW, Hitchings RA, Noureddin BN. Efect of surgery on visual field progression in normal-tension glaucoma. Ophthalmology ,1997;104:1131-1137
24 Onda E, Cioffi GA, Bacon DR, Van Buskirk EM. Microvasculature of the human optic nerve. Am J Ophthalmol ,1996;121(4):452-453
25 Levy NS. The effect of interruption of the short posterior ciliary arteries on slow axoplasmic transport and histology within the optic nerve of the rhesus monkey. Invest Ophthalmol ,1976;15(6):495-499
26徐晓红，廖天江，严灿荣，刘锋. 不同类型青光眼彩色多普勒血流显像的比较研究.中国医学影像技术，2004;20（10）:1552-1554
27 Ravalico G, Pastori G, Toffoli G,Croce M. Visual and blood flow responses in low-tension glaucoma. Surv Ophthalmol ,1994;38(Suppl):173-176
28 Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC. Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol ,1995;113(2):216-221
29葛坚，周文炳，诸建初.青光眼视功能损害与血液流变学、眼血流图及其它诸影响因素相互关系的研究.中华眼科杂志，1992;28(4):195
30 Gass A，Flammer J，Linder L，Romerio SC, Gasser P, Haefeli WE. Inverse correlation between endothelin-1-induced peripheral microvascular vasoconstriction and blood pressure in glaucoma patients. Graefes Arch Clin Exp Ophthalmol ,1997;235(10):634-638
31 Klaver JH, Greve EL, Goslinga H, Geijssen HC, Heuvelmans JH. Blood and plasma viscosity measurements in patients with glaucoma．Br J Ophthalmol，1985;69:765-770
32张伟,尹格平，张康兰，孙晓明，王焕旭.原发性青光眼外周血淋巴细胞CD44和CD54检出的临床意义.眼科新近展，1998；18(1)：13
33 Kremmer S, Kreuzfelder E, Klein R, Bontke N, Henneberg-Quester KB, Steuhl KP, Grosse-Wilde H. Antiphosphatidylserine antibodies are elevated in normal tension glaucoma. Clin Exp Immunol ,2001;125(2):211-215
34张莉,朱英.视网膜神经纤维层检查在青光眼早期诊断中的应用.国际眼科杂志,2005;5(4):724-726
35 Yang J, Tezel G, Patil RV, Romano C, Wax MB. Serum Autoantibody against Glutathione S-Transferase in Patients with Glaucoma. Invest Ophthalmol Vis Sci ,2001;42(6):1273-1276
36张莉,贝尔提·哈地尔,朱英.视网膜神经纤维层检查在青光眼早期诊断中的应用分析.国际眼科杂志,2004;4(6):1048-1051
37王建文,孙慧敏.开角型青光眼相关基因的研究.国际眼科杂志,2005;5(4):711-714
当前位置：